In spite of + noun/-ing form - "несмотря на" (предлог), употребляется всегда с предлогом "of". Despite + noun - тоже "несмотря на" (предлог), после него всегда употребляется существительное. Although - "хотя", союз.
He has won the race in spite of the difficulties. He has won the race despite the difficulties. He has won the race although he had a lot of difficulties.
Despite + noun - тоже "несмотря на" (предлог), после него всегда употребляется существительное.
Although - "хотя", союз.
He has won the race in spite of the difficulties.
He has won the race despite the difficulties.
He has won the race although he had a lot of difficulties.